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Skin rashIf you develop a skin rashstop taking this medication and contact your doctorThe skin rash may be the first sign of a serious allergic reaction to the medication.

A few cases of reversible clinical hepatotoxicity have been noted in patients taking Zyloprimand in some patientsasymptomatic rises in serum alkaline phosphatase or serum transaminase have been observedIf anorexiaweight lossor pruritus develop in patients on Zyloprimevaluation of liver function should be part of their diagnostic workupIn patients with pre-existing liver diseaseperiodic liver function tests are recommended during the early stages of therapy.

The clearance of oxipurinol is increased by uricosuric drugsand as a consequencethe addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acidIn practicethe net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the competence of the patient’s renal function.

The clearance of oxipurinol is increased by uricosuric drugsand as a consequencethe addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acidIn practicethe net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the competence of the patient’s renal function.

Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic diseaseexcept leukemiain the presence of ZyloprimHoweverin a well-controlled study of patients with lymphoma on combination therapyZyloprim did not increase the marrow toxicity of patients treated with cyclophosphamidedoxorubicinbleomycinprocarbazineand/or mechlorethamine.

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