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It is not known whether this drug is excreted in human milkBecause many drugs are excreted in human milkcaution should be exercised when rizatriptan are administered to women who are breastfeedingRizatriptan is extensively excreted in rat milkat a level of fivefold or greater than maternal plasma levels.

Patients with rare hereditary problems of galactose intolerancethe Lapp-lactase deficiency or glucose-galactose malabsorption should not take this medicine.

RIZACT Tablets are not intended for the prophylactic therapy of migraine or for use in the management of haemiplegic or basilar migraineSafety and effectiveness of RIZACT Tablets have not been established for cluster headachewhich is present in an olderpredominantly male population.

Rizatriptan should only be used where a clear diagnosis of migraine has been establishedRizatriptan should not be administered to patients with basilar or haemiplegic migraineAs with other 5-HT 1B1D agonistssensations of tightnesspainpressure and heaviness have been reported after treatment with rizatriptan in the precordiumthroatneck and jawThese events have not been associated with arrhythmias or definite ischaemic electrocardiogramECGchanges in clinical trialsone patient experienced chest pain with possible ischaemic ECG changesBecause drugs in this class may cause coronary artery vasospasmpatients who experience signs or symptoms suggestive of angina following dosing should be evaluated for the presence of coronary artery diseaseCADor a predisposition to Prinzmetal’s variant angina before receiving additional doses of medicationand should be monitored by ECG if dosing is resumed and similar symptoms recurSimilarlypatients who experience other symptoms or signs suggestive of decreased arterial flowsuch as ischaemic bowel syndrome or Raynaud’s syndrome following the use of any 5-HT 1 agonist are candidates for further evaluation.

Rizatriptan binds with high affinity to human cloned 5-HT 1B and 5-HT 1D receptorsRizatriptan has a weak affinity for other 5-HT 1 receptor subtypes5-HT 1A5-HT 1E5-HT 1Fand the 5-HT 7 receptorbut has no significant activity at 5-HT 25-HT 3alphaand beta-adrenergicdopaminergichistaminergicmuscarinic or benzodiazepine receptors.

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